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Fast Field Cycling (FFC) NMR relaxometry – Stelar

Fast Field Cycling (FFC) NMR Relaxometry

Stelar Spinmaster FFC2000

FFC NMR relaxometry is a low-field magnetic resonance technique which is non-destructive and performed from a few kHz up to approximately 100 MHz. By measuring the nuclear spin-lattice constant 1/T1 over a large range of magnetic field strengths, one obtains information that is connected to the molecular dynamics of a substance or complex material. The technique is particularly useful in revealing information on slow molecular dynamics which can only be carried out at very low magnetic field strengths. Fast Field Cycling (FFC) NMR relaxometry is an important analytical tool in industrial and academic environments, and has been successfully applied to characterize materials in fields such as: pharmaceuticals, cosmetics, polymers, petroleum, electronics and food.

In 1994, Stelar began development of advanced instrumentation for a novel low-field NMR technique, called Fast Field Cycling (FFC) NMR relaxometry. This eventually allowed Stelar to introduce the first commercial FFC NMR instrument in 1997: the Spinmaster FFC. Stelar gained a strong reputation through their experience and unique innovative technology, and has become an industry leader in FFC NMR relaxometry.

Examples of molecular dynamics information obtained through FFC NMR relaxometry:

  • Characterization of rotational dynamics.
  • Determination of thermal activation energies.
  • Characterization of surface exchange effects with solvents and other small molecules.
  • Characterization of porous systems and local diffusion effects.
  • Characterization of translational diffusion in bulk and geometrically restricted environments.
  • Identification of the presence of paramagnetic substances.
  • Identification of effects connected to cross-linking in polymers.
  • Separation of amorphous and crystalline contributions in solids.
  • Determination of aggregation states of complex biomolecules such as proteins.

Models

Stelar Spinmaster FFC2000

Stelar's Spinmaster FFC2000 is a 1 tesla research grade fast field cycling NMR relaxometer designed to measure the field dependence of the NMR longitudinal spin-lattice relaxation time, T1. The transverse spin-spin relaxation time, T2, may also be measured. The Spinmaster allows measurement of NMRD profiles from a few kHz to a maximum operating magnetic field of 42.6 MHz (1H Larmor frequency) and is capable of multi-nuclear measurements. It offers superb performance for numerous applications where investigation of molecular dynamics may provide the key to solving problems for which other analytical techniques are unable to provide answers

Features

  • Measurement of relaxation times from a fraction of a millisecond to several seconds.
  • Multi-nuclear operations.
  • Fully automated acquisition of NMRD profiles.
  • Efficient and accurate temperature control (range from -140° C to +140° C with a 0.1° C resolution).
  • Minimum operating costs (no cryogenic gases necessary).
  • No complicated sample preparation required.
  • Measures solids, liquids, liquid crystals, colloids, complex mixtures.

Stelar Products Data Sheet

Stelar SMARtracer

Stelar's SMARtracer™ is a cost-effective, bench top version of their fast field cycling NMR relaxometer that has a 0.25 tesla magnetic field. It is designed to measure the field dependence of the NMR longitudinal spin-lattice relaxation time, T1. The transverse spin-spin relaxation time, T2, may also be measured. The SMARtracer allows measurement of NMRD profiles from a 10 kHz to 10 MHz (1H Larmor frequency) and is capable of measuring fluorine as well as the proton nucleus. It is the ideal instrument to exploit the high quantity of information contained in the NMRD profiles acquired by means of fast field cycling NMR relaxometry techniques, in clinical and industrial applications.

Features

  • Measurement of relaxation times from a fraction of a millisecond to several seconds.
  • Multi-nuclear operations.
  • Fully automated acquisition of NMRD profiles.
  • Efficient and accurate temperature control (range from -140° C to +140° C with a 0.1° C resolution).
  • Minimum operating costs (no cryogenic gases necessary).
  • No complicated sample preparation required.
  • Measures solids, liquids, liquid crystals, colloids, complex mixtures.

Stelar Products Data Sheet

Stelar 3 tesla cryogen-free superconducting magnet

Combining a 3 tesla cryogen-free superconducting magnet with either Spinmaster or SMARtracer™ allows extension of the magnetic field strength range for the acquisition of NMRD profiles that is similar to the range of the latest high field clinical MRI scanner. The combined systems are ideal for studying relaxivity of MRI contrast agents. The system was developed in collaboration with HTS-110, a leading company in the design of high temperature superconducting magnetic solutions.

Features

  • Full Integration and Compatibility with Spinmaster or SMARtracer systems.
  • Variable field from 0 to 3 tesla.
  • Allows measurement of spin relaxation times up to 125 MHz.
  • Cryogen-free operation.
  • High uniformity over the whole excitation range.
  • Large 25 mm pole gap.
  • Low fringe magnetic field.
  • Reliable mechanical cooling.
  • Compact size.

Stelar Products Data Sheet

Stelar PC-NMR

Stelar's PC-NMR is a high performance, general purpose, portable NMR console. It is available in two formats: a 19" rack version or portable aluminum case version. Its innovative design provides a single and powerful "plug-and-go" solution for most NMR, NMR Fast Field Cycling, Diffusion NMR, and NQR experiments.

Features

  • Direct digital signal detection from 500 kHz up to 80 MHz (optional up to 130 MHz).
  • Three independent RF TX channels programmable from DC to 80 MHz (optional from DC to 130 MHz).
  • Data accumulation in four separate buffers (real and imaginary parts, phase and absolute value of the signal).
  • 250 W / 500 kHz - 130 MHz RF linear RF power pulse amplifier.
  • RF front end composed of: one H-range broad-band low-noise short dead-time preamplifier from 0.5-200 MHz (optional 5-400 MHz); one TX/RX coupling, and probe tuning device on computer screen.

Stelar Products Data Sheet

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